Genolevures complete genomes provide data and tools for comparative genomics of hemiascomycetous yeasts.

David James Sherman (1, 2) , Pascal Durrens (1, 2) , Florian Iragne (1, 2) , Emmanuelle Beyne (1, 2) , Macha Nikolski (1, 2) , Jean-Luc Souciet (3)

1 LaBRI - Laboratoire Bordelais de Recherche en Informatique
2 MAGNOME - Models and Algorithms for the Genome
3 GMGM - Génétique moléculaire, génomique, microbiologie

The G?levures online database (http://cbi.labri.fr/Genolevures/) provides tools and data relative to 4 complete and 10 partial genome sequences determined and manually annotated by the G?levures Consortium, to facilitate comparative genomic studies of hemiascomycetous yeasts. With their relatively small and compact genomes, yeasts offer a unique opportunity for exploring eukaryotic genome evolution. The new version of the G?levures database provides truly complete (subtelomere to subtelomere) chromosome sequences, 25 000 protein-coding and tRNA genes, and in silico analyses for each gene element. A new feature of the database is a novel collection of conserved multi-species protein families and their mapping to metabolic pathways, coupled with an advanced search feature. Data are presented with a focus on relations between genes and genomes: conservation of genes and gene families, speciation, chromosomal reorganization and synteny. The G?levures site includes an area for specific studies by members of its international community.

Domaines: Génétique

David James Sherman, Pascal Durrens, Florian Iragne, Emmanuelle Beyne, Macha Nikolski, et al.. Genolevures complete genomes provide data and tools for comparative genomics of hemiascomycetous yeasts.. Nucleic Acids Research, 2006, 34 (Database issue), pp.D432-5. ⟨10.1093/nar/gkj160⟩. ⟨hal-00118142⟩