Professional exposure to goats increases the risk of pneumonic-type lung adenocarcinoma: results of the IFCT-0504-Epidemio study.

Delphine Lutringer-Magnin (1, 2) , Nicolas Girard , Jacques Cadranel (3) , Caroline Leroux (4) , Elisabeth Quoix (5) , Vincent Cottin (6, 7) , Corinne del Signore (1) , Marie-Paule Lebitasy , Geneviève Cordier , Philippe Vanhems (8) , Jean-François Mornex (9)

1 LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
2 Centre Léon Bérard [Lyon]
3 Interactions cellulaires tumorales et leur environnement et réponse aux agents anti-cancéreux
4 RPC - Rétrovirus et Pathologie Comparée
5 Service de pneumologie
6 Department of Pneumology [Lyon]
7 Centre de Référence des Maladies Pulmonaires Rares [Hôpital Louis Pradel - HCL]
8 Service d'Hygiène, Epidémiologie et Prévention [Hôpital Edouard Herriot - HCL]
9 UCBL - Université Claude Bernard Lyon 1

Pneumonic-type lung adenocarcinoma (P-ADC) represents a distinct subset of lung cancer with specific clinical, radiological, and pathological features. Given the weak association with tobacco-smoking and the striking similarities with jaagsiekte sheep retrovirus (JSRV)-induced ovine pulmonary adenocarcinoma, it has been suggested that a zoonotic viral agent infecting pulmonary cells may predispose to P-ADC in humans. Our objective was to explore whether exposure to domestic small ruminants may represent a risk factor for P-ADC. We performed a multicenter case-control study recruiting patients with P-ADC as cases and patients with non-P-ADC non-small cell lung cancer as controls. A dedicated 356-item questionnaire was built to evaluate exposure to livestock. A total of 44 cases and 132 controls were included. At multivariate analysis, P-ADC was significantly more associated with female gender (Odds-ratio (OR) = 3.23, 95% confidence interval (CI): 1.32-7.87, p = 0.010), never-smoker status (OR = 3.57, 95% CI: 1.27-10.00, p = 0.015), personal history of extra-thoracic cancer before P-ADC diagnosis (OR = 3.43, 95% CI: 1.10-10.72, p = 0.034), and professional exposure to goats (OR = 5.09, 95% CI: 1.05-24.69, p = 0.043), as compared to other subtypes of lung cancer. This case-control suggests a link between professional exposure to goats and P-ADC, and prompts for further epidemiological evaluation of potential environmental risk factors for P-ADC.

Domaines: Sciences du Vivant [q-bio]

Delphine Lutringer-Magnin, Nicolas Girard, Jacques Cadranel, Caroline Leroux, Elisabeth Quoix, et al.. Professional exposure to goats increases the risk of pneumonic-type lung adenocarcinoma: results of the IFCT-0504-Epidemio study.. PLoS ONE, 2012, 7 (5), pp.e37889. ⟨10.1371/journal.pone.0037889⟩. ⟨hal-00965826⟩