Norine: a powerful resource for novel nonribosomal peptide discovery

Maude Pupin (1, 2) , Qassim Esmaeel (3) , Areski Flissi (1, 2) , Yoann Dufresne (1, 2) , Philippe Jacques (3) , Valérie Leclère (1, 2, 3)

1 CRIStAL - Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189
2 BONSAI - Bioinformatics and Sequence Analysis
3 ICV - Institut Charles Viollette (ICV) - EA 7394

Since its first release in 2008, Norine remains the unique resource completely devoted to nonribosomal peptides (NRPs). They are very attractive microbial secondary metabolites, displaying a remarkable diversity of structure and functions. Norine (http://bioinfo.lifl.fr/NRP) includes a database now containing more than 1160 annotated peptides and user-friendly interfaces enabling the querying of the database, through the annotations or the structure of the peptides. Dedicated tools are associated for structural comparison of the compounds and prediction of their biological activities. In this paper, we start by describing the knowledgebase and the dedicated tools. We then present some user cases to show how useful Norine is for the discovery of novel nonribosomal peptides.

Mots clés: Norine; nonribosomal peptides; secondary metabolites; database

Domaines: Bio-informatique [q-bio.QM]

Maude Pupin, Qassim Esmaeel, Areski Flissi, Yoann Dufresne, Philippe Jacques, et al.. Norine: a powerful resource for novel nonribosomal peptide discovery. Synthetic and Systems Biotechnology, 2015, ⟨10.1016/j.synbio.2015.11.001⟩. ⟨hal-01250614⟩