The role of abnormal inhibitory transmission at the gap junctions of cardiac cells in fibrillation
Résumé
The noisy aspect of data recorded by electrodes, on the inner surface of human atria during episodes of atrial fibrillation, exhibit intriguing features for excitable media. Instead of phase chaos as typically expected, it shares many common traits of non-equilibrium fluctuations in disordered systems or strong turbulence. To assess those peculiar observations we investigate a synaptic plasticity that affects conduction properties. Electrical synapses comprise many different kinds of connexins, which may be affected by diverse factors, so we use a generic approach. Slight detuning of their linear response leads to an instability of the modulating agents, here an excess charge. Acting on slow time scales of repolarisation, it is understood as collective modes propagating through and retroacting on each synapse: The medium is desynchronised. It is not a syncytium. Transient states are here associated with a phenomenon called electrical remodelling, which has not received any accepted description thus far. Moreover, from the properties of the model it is possible to start exploring phase space. Transitions between different regimes could help decipher stages in the evolution of the disease from acute to chronic, one main goal of cardiovascular research.
Origine : Fichiers produits par l'(les) auteur(s)