Improved Vascular Transport Function Characterization in DSC-MRI via Deconvolution with Dispersion-Compliant Bases

Marco Pizzolato (1) , Rutger H.J. Fick (1) , Timothé Boutelier (2) , Rachid Deriche (1)

1 ATHENA - Computational Imaging of the Central Nervous System
2 Olea Medical [La Ciotat]

Bolus dispersion affects the residue function computed via deconvolution of DSC-MRI data. The obtained effective residue function can be expressed as the convolution of the true one with a Vascular Transport Function (VTF) that characterizes dispersion. The state-of-the-art technique CPI+VTF allows to estimate the actual residue function by assuming a model of VTF. We propose to perform deconvolution representing the effective residue function with Dispersion-Compliant Bases (DCB) with no assumptions on the VTF, and then apply the CPI+VTF on DCB results, to improve performance.

Mots clés: vascular transport function; bases; deconvolution; perfusion; MRI; Dynamic Susceptibility Contrast; dispersion

Domaines: Imagerie médicale

Marco Pizzolato, Rutger H.J. Fick, Timothé Boutelier, Rachid Deriche. Improved Vascular Transport Function Characterization in DSC-MRI via Deconvolution with Dispersion-Compliant Bases. ISMRM 2016, May 2016, Singapore, Singapore. ⟨hal-01358775⟩