Impact of fat mass and distribution on lipid turnover in human adipose tissue

Kirsty L Spalding (1) , Samuel Bernard (2, 3, 4) , Erik Näslund (5) , Mehran Salehpour (6) , Göran Possnert (6) , Lena L Appelsved (1) , Keng-Yeh Fu (7, 8) , Kanar Alkass (1, 9) , Henrik Druid (9) , Anders Thorell (10) , Mikael Rydén (11) , Peter Arner (11)

1 Department of Cell and Molecular Biology [Stockholm]
2 DRACULA - Multi-scale modelling of cell dynamics : application to hematopoiesis
3 ICJ - Institut Camille Jordan
4 MMCS - Modélisation mathématique, calcul scientifique
5 Division of Surgery, Department of Clinical Sciences
6 Department of Physics and Astronomy [Uppsala]
7 NAU - Nanjing Agricultural University
8 Jiangsu Academy of Agricultural Sciences
9 Department of Forensic Medicine [Stockholm]
10 Danderyds sjukhus = Danderyd University Hospital
11 Department of medicine [Stockholm]

Differences in white adipose tissue (WAT) lipid turnover between the visceral (vWAT) and subcutaneous (sWAT) depots may cause metabolic complications in obesity. Here we compare triglyceride age and, thereby, triglyceride turnover in vWAT and sWAT biopsies from 346 individuals and find that subcutaneous triglyceride age and storage capacity are increased in overweight or obese individuals. Visceral triglyceride age is only increased in excessively obese individuals and associated with a lower lipid removal capacity. Thus, although triglyceride storage capacity in sWAT is higher than in vWAT, the former plateaus at substantially lower levels of excess WAT mass than vWAT. In individuals with central or visceral obesity, lipid turnover is selectively increased in vWAT. Obese individuals classified as 'metabolically unhealthy' (according to ATPIII criteria) who have small subcutaneous adipocytes exhibit reduced triglyceride turnover. We conclude that excess WAT results in depot-specific differences in lipid turnover and increased turnover in vWAT and/or decreased turnover in sWAT may result in metabolic complications of overweight or obesity.

Domaines: Systèmes dynamiques [math.DS]

Kirsty L Spalding, Samuel Bernard, Erik Näslund, Mehran Salehpour, Göran Possnert, et al.. Impact of fat mass and distribution on lipid turnover in human adipose tissue. Nature Communications, 2017, 8, pp.15253. ⟨10.1038/ncomms15253⟩. ⟨hal-01561605⟩