Towards the assessment of myelination using time-dependent diffusion MRI indices

Abib Alimi (1, 2) , Alexandra Petiet (3) , Mathieu Santin (3) , Anne-Charlotte Philippe (3) , Stéphane Lehéricy (3) , Rachid Deriche (1, 2) , Demian Wassermann (1, 4)

1 ATHENA - Computational Imaging of the Central Nervous System
2 COMUE UCA - COMUE Université Côte d'Azur (2015-2019)
3 CENIR - Plateforme de neuroimagerie CENIR = Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris]
4 CEA - Commissariat à l'énergie atomique et aux énergies alternatives

Synopsis We study the sensitivity of time-dependent diffusion MRI indices or qτ-indices to demyelination in the mouse brain. For this, we acquire in vivo four-dimentional diffusion-weighted images-varying over gradient strength, direction and diffusion time-and estimate the qτ-indices from the corpus callosum. First order Taylor approximation of each index gives fitting coefficients α and β whose variance we investigate. Results indicate that, cuprizone intoxication affects mainly index coefficient β by introducing inequality of variances between the two mice groups, most significantly in the splenium and that MSD increases and RTOP decreases over diffusion time τ.

Domaines: Imagerie médicale; Traitement du signal et de l'image [eess.SP]

Abib Alimi, Alexandra Petiet, Mathieu Santin, Anne-Charlotte Philippe, Stéphane Lehéricy, et al.. Towards the assessment of myelination using time-dependent diffusion MRI indices. ISMRM 2018 - International Society for Magnetic Resonance in Medicine, Jun 2018, Paris, France. pp.1-4. ⟨hal-01723846⟩