Model-based Feature Augmentation for Cardiac Ablation Target Learning from Images

Rocio Cabrera Lozoya (1) , Benjamin Berte (2) , Hubert Cochet (2) , Pierre Jaïs (2) , Nicholas Ayache (1, 3) , Maxime Sermesant (1)

1 ASCLEPIOS - Analysis and Simulation of Biomedical Images
2 IHU-LIRYC
3 EPIONE - E-Patient : Images, données & mOdèles pour la médeciNe numériquE

Goal: We present a model-based feature augmentation scheme to improve the performance of a learning algorithm for the detection of cardiac radio-frequency ablation (RFA) targets with respect to learning from images alone. Methods: Initially, we compute image features from delayed-enhanced MRI (DE-MRI) to describe local tissue heterogeneities and feed them into a machine learning framework with uncertainty assessment for the identification of potential ablation targets. Next, we introduce the use of a patient-specific image-based model derived from DE-MRI coupled with the Mitchell-Schaeffer electrophysiology model and a dipole formulation for the simulation of intracardiac electrograms (EGM). Relevant features are extracted from these simulated signals which serve as a feature augmentation scheme for the learning algorithm. We assess the classifier's performance when using only image features and with model-based feature augmentation. Results: We obtained average classification scores of 97.2% accuracy, 82.4% sensitivity and 95.0% positive predictive value (PPV) by using a model-based feature augmentation scheme. Preliminary results also show that training the algorithm on the closest patient from the database, instead of using all the patients, improves the classification results. Conclusion: We presented a feature augmentation scheme based on biophysical cardiac electrophysiology modeling to increase the prediction scores of a machine learning framework for the RFA target prediction. Significance: The results derived from this study are a proof of concept that the use of model-based feature augmentation strengthens the performance of a purely image driven learning scheme for the prediction of cardiac ablation targets.

Mots clés: intracardiac electrogram modelling; cardiac elec-; Index Terms—radio-frequency ablation planning; trophysiology modelling; electroanatomical mapping

Domaines: Imagerie médicale; Intelligence artificielle [cs.AI]; Traitement du signal et de l'image [eess.SP]; Mathématiques [math]; Sciences de l'ingénieur [physics]; Physique [physics]

Rocio Cabrera Lozoya, Benjamin Berte, Hubert Cochet, Pierre Jaïs, Nicholas Ayache, et al.. Model-based Feature Augmentation for Cardiac Ablation Target Learning from Images. IEEE Transactions on Biomedical Engineering, 2018, pp.1. ⟨10.1109/TBME.2018.2818300⟩. ⟨hal-01744142⟩