Interplay among distinct Ca 2+ conductances drives Ca 2+ sparks/spontaneous transient outward currents in rat cerebral arteries

Ahmed Hashad (1) , Neil Mazumdar (2) , Monica Romero (3) , Anders Nygren (1) , Kamran Bigdely-Shamloo (1) , Osama Harraz (4) , Jose Puglisi (5) , Edward Vigmond (6) , Sean Wilson (7) , Donald Welsh (1, 2)

1 University of Calgary
2 UWO - University of Western Ontario
3 Loma Linda University
4 University of Vermont [Burlington]
5 CNSU - California Northstate University
6 CARMEN - Modélisation et calculs pour l'électrophysiologie cardiaque
7 School of Informatics [Edimbourg]

Distinct Ca2+ channels work in a coordinated manner to grade Ca2+ spark/spontaneous transient outward currents (STOCs) in rat cerebral arteries. The relative contribution of each Ca2+ channel to Ca2+ spark/STOC production depends upon their biophysical properties and the resting membrane potential of smooth muscle. Na+ /Ca2+ exchanger, but not TRP channels, can also facilitate STOC production.

Mots clés: BKCa channels; Ca2+ channels; Ca2+ spark; cerebral arteries

Domaines: Cardiologie et système cardiovasculaire

Ahmed Hashad, Neil Mazumdar, Monica Romero, Anders Nygren, Kamran Bigdely-Shamloo, et al.. Interplay among distinct Ca 2+ conductances drives Ca 2+ sparks/spontaneous transient outward currents in rat cerebral arteries. The Journal of Physiology, 2017, 595 (4), pp.1111-1126. ⟨10.1113/JP273329⟩. ⟨hal-02885672⟩