Stochastic spontaneous calcium release events trigger premature ventricular complexes by overcoming electrotonic load

Fernando Campos (1) , Yohannes Shiferaw (2) , Anton J Prassl (1) , Patrick Boyle (3) , Edward Vigmond (4) , Gernot N Plank (5)

1 Medical University Graz
2 CSUN - California State University [Northridge]
3 JHU - Johns Hopkins University
4 CARMEN - Modélisation et calculs pour l'électrophysiologie cardiaque
5 ESTEC - European Space Research and Technology Centre

Premature ventricular complexes (PVCs) due to spontaneous calcium (Ca) release (SCR) events at the cell level can precipitate ventricular arrhythmias. However, the mechanistic link between SCRs and PVC formation remains incompletely understood. The aim of this study was to investigate the conditions under which delayed afterdepolarizations resulting from stochastic subcellular SCR events can overcome electrotonic source-sink mismatch, leading to PVC initiation.

Mots clés: Delayed afterdepolarization; Computer-based model; Triggered activity; Purkinje system; Arrhythmia

Domaines: Biophysique; Cardiologie et système cardiovasculaire

Fernando Campos, Yohannes Shiferaw, Anton J Prassl, Patrick Boyle, Edward Vigmond, et al.. Stochastic spontaneous calcium release events trigger premature ventricular complexes by overcoming electrotonic load. Cardiovascular Research, 2015, 107 (1), pp.175-183. ⟨10.1093/cvr/cvv149⟩. ⟨hal-02886267⟩