Functional connectivity is preserved but reorganized across several anesthetic regimes

Guillaume Jean-Paul Claude Becq (1, 2) , Tarik Habet (3) , Nora Collomb (3) , Margaux Faucher (3) , Chantal Delon-Martin (3) , Véronique Coizet (3) , Sophie Achard (4) , Emmanuel Luc Barbier (3)

1 GIPSA-GAIA - GIPSA Pôle Géométrie, Apprentissage, Information et Algorithmes
2 GIPSA-Services - GIPSA-Services
3 GIN - [GIN] Grenoble Institut des Neurosciences
4 STATIFY - Modèles statistiques bayésiens et des valeurs extrêmes pour données structurées et de grande dimension

Under anesthesia, systemic variables and CBF are modified. How does this alter the connectivity measures obtained with rs-fMRI? To tackle this question, we explored the effect of four different anesthetics on Long Evans and Wistar rats with multimodal recordings of rs-fMRI, systemic variables and CBF. After multimodal signal processing, we show that the blood-oxygen-level-dependent (BOLD) variations and functional connectivity (FC) evaluated at low frequencies (0.031-0.25 Hz) do not depend on systemic variables and are preserved across a large interval of baseline CBF values. Based on these findings, we found that most brain areas remain functionally active under any anesthetics, i.e. connected to at least one other brain area, as shown by the connectivity graphs. In addition, we quantified the influence of nodes by a measure of functional connectivity strength to show the specific areas targeted by anesthetics and compare correlation values of edges at different levels. These measures enable us to highlight the specific network alterations induced by anesthetics. Altogether, this suggests that changes in connectivity could be evaluated under anesthesia, routinely used in the control of neurological injury.

Mots clés: anesthesia; cerebral blood flow (CBF); functional connectivity (FC); rat; resting state functional magnetic resonant imaging (rs-fMRI); systemic variables

Mots clés: Anesthésie générale; Flux cérébral; Cerveau de rat; Imagerie fonctionnelle par résonance magnétique en temps réel; Variables systémiques; rat

Domaines: Neurosciences [q-bio.NC]; Biologie animale; Traitement du signal et de l'image [eess.SP]; Imagerie

Guillaume Jean-Paul Claude Becq, Tarik Habet, Nora Collomb, Margaux Faucher, Chantal Delon-Martin, et al.. Functional connectivity is preserved but reorganized across several anesthetic regimes. NeuroImage, 2020, 219, pp.116945. ⟨10.1016/j.neuroimage.2020.116945⟩. ⟨hal-02935430⟩