Brain connectivity reduction reflects disturbed self-organisation of the brain: Neural disorders and General Anesthesia

Axel Hutt (1)

1 MIMESIS - Computational Anatomy and Simulation for Medicine

The neurophysiological correlate of functional neural impairment is an open problem. Functional impairment may be observed as mental disorder, seizures or modification of consciousness level. The latter include loss of responsiveness under general anaesthesia, sleep or even trance in hypnosis. This chapter points out the relation between reduced brain connectivity as a possible correlate of neural functional impairment and self-organisation in the brain. A first numerical example demonstrates how neural noise disturbs self-organisation in the brain. Estimators of self-organisation such as global phase synchrony or information transfer quantify the degree of self-organisation. The chapter shows up by a brief literature review how these estimators indicate brain connectivity modifications in neural disorders and under general anaesthesia.

Mots clés: unconsciousness; Alzheimer disease; Parkinson disease; multiple scle- rosis; noise-induced transition

Domaines: Modélisation et simulation

Axel Hutt. Brain connectivity reduction reflects disturbed self-organisation of the brain: Neural disorders and General Anesthesia. V. Cutsuridis, Multiscale models of Brain Disorders, 2019. ⟨hal-02939242⟩