Impact of Mitral Regurgitation Severity and Left Ventricular Remodeling on Outcome After Mitraclip Implantation: Results From the Mitra-FR Trial

David Messika-Zeitoun (1) , Bernard Iung (2, 3) , Xavier Armoiry (4, 5) , J.-N. Trochu (6, 7) , Erwan Donal (8, 9) , Gilbert Habib (10, 11, 12) , Eric Brochet (3) , Hélène Thibault (13) , Nicolas Piriou (6, 7) , Bertrand Cormier (14) , Christophe Tribouilloy (15, 16) , Patrice Guérin (6, 7, 17) , Thierry Lefèvre (14) , Delphine Maucort-Boulch (18, 19, 20) , Alec Vahanian (2) , Florent Boutitie (18, 19) , J.-F. Obadia (21, 19, 22)

1 University of Ottawa Heart Institute
2 LVTS (UMR_S_1148 / U1148) - Laboratoire de Recherche Vasculaire Translationnelle
3 AP-HP - Hôpital Bichat - Claude Bernard [Paris]
4 MATEIS - Matériaux, ingénierie et science [Villeurbanne]
5 Hôpital Edouard Herriot [CHU - HCL]
6 CHU Nantes - Centre Hospitalier Universitaire de Nantes
7 Institut du Thorax [Nantes]
8 LTSI - Laboratoire Traitement du Signal et de l'Image
9 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
10 MEPHI - Microbes évolution phylogénie et infections
11 TIMONE - Hôpital de la Timone [CHU - APHM]
12 IHU Marseille - Institut Hospitalier Universitaire Méditerranée Infection
13 GHE - Groupement Hospitalier Lyon-Est
14 Hôpital Privé Jacques Cartier [Massy]
15 MP3CV - Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517
16 CHU Amiens-Picardie
17 RMeS - Regenerative Medicine and Skeleton
18 LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
19 HCL - Hospices Civils de Lyon
20 Service de Biostatistiques [Lyon]
21 Hôpital Louis Pradel [CHU - HCL]
22 UCBL - Université Claude Bernard Lyon 1

Objectives - This study aimed to identify a subset of patients based on echocardiographic parameters who might have benefited from transcatheter correction using the Mitraclip system in the MITRA-FR (Percutaneous Repair with the MitraClip Device for Severe Functional/Secondary Mitral Regurgitation) trial. Background - It has been suggested that differences in the degree of mitral regurgitation (MR) and left ventricular (LV) remodeling may explain the conflicting results between the MITRA-FR and the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation) trials. Methods - In a post hoc analysis, we evaluated the interaction between the intervention and subsets of patients defined based on MR severity (effective regurgitant orifice [ERO], regurgitant volume [RVOL] and regurgitant fraction [RF]), LV remodeling (end-diastolic and end-systolic diameters and volumes) and combination of these parameters with respect to the composite of death from any cause or unplanned hospitalization for heart failure at 24 months. Results - We observed a neutral impact of the intervention in subsets with the highest MR degree (ERO ≥30 mm, RVOL ≥45 ml or RF ≥50%) as in patients with milder MR degree. The same was seen in subsets with the milder LV remodeling using either diastolic or systolic diameters or volumes. When parameters of MR severity and LV remodeling were combined, there was still no benefit of the intervention including in the subset of patients with an ERO/end-diastolic volume ratio ≥ 0.15 despite similar ERO and LV end-diastolic volume compared with COAPT patients. Conclusions - In the MITRA-FR trial, we could not identify a subset of patients defined based on the degree of the regurgitation, LV remodeling or on their combination, including those deemed as having disproportionate MR, that might have benefited from transcatheter correction using the Mitraclip system. (Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation [MITRA-FR]; NCT01920698).

Mots clés: mitral regurgitation; outcomes; transcatheter mitral valve therapy

Domaines: Ingénierie biomédicale

David Messika-Zeitoun, Bernard Iung, Xavier Armoiry, J.-N. Trochu, Erwan Donal, et al.. Impact of Mitral Regurgitation Severity and Left Ventricular Remodeling on Outcome After Mitraclip Implantation: Results From the Mitra-FR Trial. JACC: Cardiovascular Imaging, 2021, 14 (4), pp.742-752. ⟨10.1016/j.jcmg.2020.07.021⟩. ⟨hal-02959038⟩