Rationally designed mRNA-loaded lipid nanoparticles provoke strong antitumor T cell immunity which critically depends on specific immune cell subsets

Sander Kooijmans (1) , Sanne Bevers (2, 3) , Elien van de Velde (2) , Martijn J W Evers (1) , Sofie Seghers (2) , Jerney J J M Gitz-François (1) , Lucie Hassler (4) , Karine Breckpot (3) , Thierry Bastogne (5, 6, 4) , Raymond M Schiffelers (1) , Stefaan de Koker (2)

1 University Medical Center [Utrecht]
2 eTheRNA Immunotherapies NV
3 VUB - Vrije Universiteit Brussel [Bruxelles]
4 CYBERnano [Villers-lès-Nancy]
5 CRAN - Centre de Recherche en Automatique de Nancy
6 BIGS - Biology, genetics and statistics

Mots clés: DNA/RNA; Vaccine (or Immunomodulatory); Nanoparticle/nanomaterial; Formulation development

Domaines: Applications [stat.AP]; Cancer; Micro et nanotechnologies/Microélectronique; Biotechnologies

Sander Kooijmans, Sanne Bevers, Elien van de Velde, Martijn J W Evers, Sofie Seghers, et al.. Rationally designed mRNA-loaded lipid nanoparticles provoke strong antitumor T cell immunity which critically depends on specific immune cell subsets. Annual Meeting of the Controlled Release Society, CRS 2021, Jul 2021, Virtual, United States. ⟨hal-03298753⟩