New perspectives on the calculation of bioaccumulation metrics for active substances in living organisms

Aude Ratier (1) , Christelle Lopes (1) , Gauthier Multari (1) , Vanessa Mazerolles (2) , Patrice Carpentier (2) , Sandrine Charles (1)

1 LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
2 DEPR - Direction de l'évaluation des produits réglementés

Today, only few ready-to-use and convenient decision-making tools are available in ecotoxicology concerning accumulation and effects of chemical substances on organisms, accounting for exposure situations that are known to be complex (routes of exposure, metabolism, mixtures, etc.). This paper presents new perspectives on the generic calculation of bioaccumulation metrics via the innovative web tool MOSAICbioacc (http://mosaic.univ-lyon1.fr/bioacc). MOSAICbioacc provides all kinds of bioaccumulation metrics associated with their uncertainty whatever the species-compound combination. MOSAICbioacc expects accumulation-depuration data as inputs, even with complex exposure and clearance patterns, to quickly perform their relevant analysis. MOSAICbioacc intends to facilitate the daily work of regulators, or any ecotoxicologist, who will freely benefit from a user-friendly online interface that automatically fits toxicokinetic models without need for users to invest in the technical aspects to get bioaccumulation metrics estimates. MOSAICbioacc also provides all results in a fully transparent way to ensure reproducibility

Mots clés: Bayesian inference; Environmental risk asessment; Toxicokinetic models; Uncertainties; User-friendly web platform

Domaines: Ingénierie de l'environnement; Ecotoxicologie

Aude Ratier, Christelle Lopes, Gauthier Multari, Vanessa Mazerolles, Patrice Carpentier, et al.. New perspectives on the calculation of bioaccumulation metrics for active substances in living organisms. Integrated Environmental Assessment and Management, 2022, 18, pp.10-18. ⟨hal-03343427⟩