Right-left ventricular shape variations in tetralogy of Fallot: associations with pulmonary regurgitation

Charlène A Mauger (1, 2) , Sachin Govil (3) , Radomir Chabiniok (4, 5, 6, 7, 8) , Kathleen Gilbert (2) , Sanjeet Hegde (3, 9) , Tarique Hussain (7) , Andrew D Mcculloch (3, 3) , Christopher J Occleshaw (10) , Jeffrey Omens (9) , James C Perry (3, 9) , Kuberan Pushparajah (11) , Avan Suinesiaputra (12) , Liang Zhong (13, 14) , Alistair A Young (11, 1)

1 University of Auckland [Auckland]
2 Auckland Bioengineering Institute
3 UC San Diego - University of California [San Diego]
4 King‘s College London
5 CTU - Czech Technical University in Prague
6 M3DISIM - Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine
7 University of Texas Southwestern Medical Center [Dallas]
8 Guy's and St Thomas' Hospital [London]
9 Rady Children's Hospital San Diego
10 Department of Cardiology, Auckland District Health Board, Auckland
11 King's College London School of Medicine at Guy's, King's College and St Thomas' Hospitals
12 University of Leeds
13 Duke-NUS Medical School [Singapore]
14 NHCS - National Heart Centre Singapore

Abstract Background Relationships between right ventricular (RV) and left ventricular (LV) shape and function may be useful in determining optimal timing for pulmonary valve replacement in patients with repaired tetralogy of Fallot (rTOF). However, these are multivariate and difficult to quantify. We aimed to quantify variations in biventricular shape associated with pulmonary regurgitant volume (PRV) in rTOF using a biventricular atlas. Methods In this cross-sectional retrospective study, a biventricular shape model was customized to cardiovascular magnetic resonance (CMR) images from 88 rTOF patients (median age 16, inter-quartile range 11.8–24.3 years). Morphometric scores quantifying biventricular shape at end-diastole and end-systole were computed using principal component analysis. Multivariate linear regression was used to quantify biventricular shape associations with PRV, corrected for age, sex, height, and weight. Regional associations were confirmed by univariate correlations with distances and angles computed from the models, as well as global systolic strains computed from changes in arc length from end-diastole to end-systole. Results PRV was significantly associated with 5 biventricular morphometric scores, independent of covariates, and accounted for 12.3% of total shape variation (p < 0.05). Increasing PRV was associated with RV dilation and basal bulging, in conjunction with decreased LV septal-lateral dimension (LV flattening) and systolic septal motion towards the RV (all p < 0.05). Increased global RV radial, longitudinal, circumferential and LV radial systolic strains were significantly associated with increased PRV (all p < 0.05). Conclusion A biventricular atlas of rTOF patients quantified multivariate relationships between left–right ventricular morphometry and wall motion with pulmonary regurgitation. Regional RV dilation, LV reduction, LV septal-lateral flattening and increased RV strain were all associated with increased pulmonary regurgitant volume. Morphometric scores provide simple metrics linking mechanisms for structural and functional alteration with important clinical indices.

Mots clés: Cardiovascular magnetic resonance; Ventricular function; Atlases; Myocardial deformation; Tetralogy of Fallot

Domaines: Ingénierie biomédicale

Charlène A Mauger, Sachin Govil, Radomir Chabiniok, Kathleen Gilbert, Sanjeet Hegde, et al.. Right-left ventricular shape variations in tetralogy of Fallot: associations with pulmonary regurgitation. Journal of Cardiovascular Magnetic Resonance, 2021, 23 (1), ⟨10.1186/s12968-021-00780-x⟩. ⟨hal-03369697⟩