The association of theory of mind with language and visuospatial abilities in amyotrophic lateral sclerosis: a pilot study

Niki Panopoulou (1) , Foteini Christidi (1) , Panagiotis Kourtesis (2) , Panagiotis Ferentinos (1) , Panagiota Karampetsou (1) , Georgios Tsirtsiridis (1) , Thomas Theodosiou (1) , Sofia Xirou (1) , Vasiliki Zouvelou (1) , Ioannis Evdokimidis (1) , Michail Rentzos (1) , Ioannis Zalonis (1)

1 NKUA - National and Kapodistrian University of Athens
2 Hybrid - 3D interaction with virtual environments using body and mind

Objective: Dysfunction of social cognition is well-recognized as one of amyotrophic lateral sclerosis (ALS) cognitive impairments. Previous studies have mostly associated social cognition subcomponents, including Theory of Mind (ToM), with executive dysfunction using highlydemanding tasks. In the present study, we investigate dysfunction of affective ToM in a sample of ALS patients without dementia and evaluate any possible associations both with executive and non-executive dysfunction. Methods: We included 42 ALS patients and 30 healthy controls (HC) and administered the Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen (ECAS). Affective ToM was examined based on the ECAS judgment of preference task; total score and type of errors ("favourite", "unclassified") were recorded for all participants. Results: A significant proportion of ALS patients (31%) were impaired on ToM task, scoring significantly lower compared to HC. Impairments in ToM task were more frequent (45%) in patients with cognitive impairment compared to those with intact cognition (15%). ALS patients showed significantly more errors on ToM task compared to HC. A significant association was found between ToM score and ECAS language and visuospatial abilities but not fluency, executive or memory function. Conclusion: Dysfunction of affective ToM appears prevalent in ALS patients without dementia, and associates with language and visuospatial abilities. These associations align with motor and extra-motor symptoms due to the degeneration across corresponding networks. Impaired ToM should be considered in clinical settings, since it might contribute to patients' social life, as well as the burden of their caregivers and relatives.

Mots clés: Amyotrophic Lateral Sclerosis; Social Cognition; Theory of Mind; Language; Visuospatial

Domaines: Sciences cognitives; Psychologie; Médecine humaine et pathologie

Niki Panopoulou, Foteini Christidi, Panagiotis Kourtesis, Panagiotis Ferentinos, Panagiota Karampetsou, et al.. The association of theory of mind with language and visuospatial abilities in amyotrophic lateral sclerosis: a pilot study. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2022, 23 (5-6), pp.462-469. ⟨10.1080/21678421.2021.2013893⟩. ⟨hal-03481504⟩