Endoscopic characterization of colorectal neoplasia with different published classifications: comparative study involving CONECCT classification

Paul Bonniaud (1) , Jérémie Jacques (2, 3) , Thomas Lambin (1) , Jean-Michel Gonzalez (3, 4) , Xavier Dray (3, 5) , Emmanuel Coron (3, 6) , Sarah Leblanc (3, 7) , Jean-Baptiste Chevaux (3, 8) , Florence Léger-Nguyen (9) , Benjamin Hamel (10) , Isabelle Lienhart (11) , Jérôme Rivory (1, 3) , Thierry Ponchon (1, 3) , Jean-Christophe Saurin (1, 3) , Frédéric Monzy (12) , Romain Legros (3) , Vincent Lépilliez (3, 7) , Fabien Subtil (1, 13, 14) , Maximilien Barret (3, 15) , Mathieu Pioche (13, 16, 1, 3)

1 HCL - Hospices Civils de Lyon
2 Hôpital Dupuytren [CHU Limoges]
3 Société Française d'Endoscopie Digestive
4 LBA UMR T24 - Laboratoire de Biomécanique Appliquée
5 CHU Saint-Antoine [AP-HP]
6 CHU Nantes - Centre Hospitalier Universitaire de Nantes
7 Clinique Jean-Mermoz
8 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
9 Clinique du Val d'Ouest
10 Hôpital Villefranche sur Saône
11 Centre Hospitalier d'Annecy
12 Hôpital-Clinique Claude-Bernard [Metz]
13 LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
14 Service de Biostatistiques [Lyon]
15 Hôpital Cochin [AP-HP]
16 LabTAU - Application des ultrasons à la thérapie

Background and study aims The aim of this study was to validate the COlorectal NEoplasia Classification to Choose the Treatment (CONECCT) classification that groups all published criteria (including covert signs of carcinoma) in a single table. Patients and methods For this multicenter comparative study an expert endoscopist created an image library (n = 206 lesions; from hyperplastic to deep invasive cancers) with at least white light Imaging and chromoendoscopy images (virtual ± dye based). Lesions were resected/biopsied to assess histology. Participants characterized lesions using the Paris, Laterally Spreading Tumours, Kudo, Sano, NBI International Colorectal Endoscopic Classification (NICE), Workgroup serrAted polypS and Polyposis (WASP), and CONECCT classifications, and assessed the quality of images on a web-based platform. Krippendorff alpha and Cohen’s Kappa were used to assess interobserver and intra-observer agreement, respectively. Answers were cross-referenced with histology. Results Eleven experts, 19 non-experts, and 10 gastroenterology fellows participated. The CONECCT classification had a higher interobserver agreement (Krippendorff alpha = 0.738) than for all the other classifications and increased with expertise and with quality of pictures. CONECCT classification had a higher intra-observer agreement than all other existing classifications except WASP (only describing Sessile Serrated Adenoma Polyp). Specificity of CONECCT IIA (89.2, 95 % CI [80.4;94.9]) to diagnose adenomas was higher than the NICE2 category (71.1, 95 % CI [60.1;80.5]). The sensitivity of Kudo Vi, Sano IIIa, NICE 2 and CONECCT IIC to detect adenocarcinoma were statistically different (P < 0.001): the highest sensitivities were for NICE 2 (84.2 %) and CONECCT IIC (78.9 %), and the lowest for Kudo Vi (31.6 %). Conclusions The CONECCT classification currently offers the best interobserver and intra-observer agreement, including between experts and non-experts. CONECCT IIA is the best classification for excluding presence of adenocarcinoma in a colorectal lesion and CONECCT IIC offers the better compromise for diagnosing superficial adenocarcinoma.

Domaines: Médecine humaine et pathologie

Paul Bonniaud, Jérémie Jacques, Thomas Lambin, Jean-Michel Gonzalez, Xavier Dray, et al.. Endoscopic characterization of colorectal neoplasia with different published classifications: comparative study involving CONECCT classification. Endoscopy International Open, 2022, 10 (01), pp.E145 - E153. ⟨10.1055/a-1613-5328⟩. ⟨hal-03539465⟩