Changes in brain perfusion in successive arterial spin labelling MRI scans in neonates with hypoxic-ischemic encephalopathy

Maïa Proisy (1) , Isabelle Corouge (1) , Antoine Legouhy (1) , Valérie Charon (2) , Nadia Mazille (2) , Amélie Nicolas (2) , Stéphanie Leroux (2) , Bertrand Bruneau (2) , Christian Barillot (1) , Jean-Christophe Ferré (3, 1)

1 Empenn - Neuroimagerie: méthodes et applications
2 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
3 Service de Neuroradiologie [Rennes]

This article proposes an innovative processing pipeline for morphological and ASL data suited to neonates that enable automated segmentation to obtain CBF values over ROIs. We evaluate CBF on two successive scans within the first 15 days of life in the same subjects. ASL imaging in asphyxiated neonates seems more relevant when used relatively early, in the first days of life. The correlation of intra-subject changes in cerebral perfusion between early and late MRI with neurodevelopmental outcome warrants investigation in a larger cohort, to determine whether the CBF pattern change can provide prognostic information beyond that provided by visible structural abnormalities on conventional MRI.

Domaines: Pédiatrie; Médecine humaine et pathologie; Ingénierie biomédicale; Neurosciences [q-bio.NC]

Maïa Proisy, Isabelle Corouge, Antoine Legouhy, Valérie Charon, Nadia Mazille, et al.. Changes in brain perfusion in successive arterial spin labelling MRI scans in neonates with hypoxic-ischemic encephalopathy. SPR 2019 - Annual Meeting & Postgraduate Course, Apr 2019, San Francisco, California, United States. ⟨inserm-01944507⟩