Inter-Hemispheric Remapping between Arm Proprioception and Vision of the Hand is Disrupted by Single Pulse TMS on the Left Parietal Cortex

Lilian Fautrelle (1) , Mathieu Gueugnon (1) , Guillaume Barbieri (1) , François Bonnetblanc (1, 2)

1 CAPS - Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093]
2 DEMAR - Artificial movement and gait restoration

Parietal cortical areas are involved in sensori-motor transformations for their respective contralateral hemifield/body. When arms of the subjects are crossed while their gaze is fixed straight ahead, vision of the hand is processed by the hemisphere ipsilateral to the arm position and proprioception of the arm by the contralateral hemisphere. It induces interhemispheric transfer and remapping. Our objective was to investigate whether a single pulse TMS applied to the left parietal cortical area would disturb interhemispheric remapping in a similar case, and would increase a simple reaction time (RT) with respect to a control single pulse TMS applied to the frontal cortical area. Two LED were superimposed and located in front of the subjects on the saggital axis. Subjects were asked to carefully fixate on these LED during each trial. The lighting of the red LED was used as a warning signal. Following the green one was illuminated after a variable delay and served as a go-signal. The hand for the response was determined before the start of each trial. TMS was applied to the left parietal, the left frontal cortical areas, or not applied to the subject. Results revealed that: (1) Irrespective of its location, single pulse TMS induced a non-specific effect similar to a startle reflex and reduced RT substantially (15 ms on average) with respect to a control condition without TMS (mean value = 153 ms). (2) Irrespective of TMS, RT were shorter when the right or the left hand was positioned in the right visual hemi-field (i.e. normal and crossed positions respectively). (3) Finally, RT increased when single pulse TMS was applied to the left parietal area and when hands were crossed irrespective of which hand was used. We concluded that interhemispheric sensori-motor remapping was disrupted by a single pulse TMS that was applied to the left parietal cortex. This effect was also combined some visual attention directed towards the hand located on the right visual hemi-field.

Mots clés: Startle reflex; Simple reaction time (RT); Left parietal area; Transcranial magnetic stimulation (TMS); Remapping; Interhemispheric transfer

Domaines: Neurosciences; Automatique / Robotique

Lilian Fautrelle, Mathieu Gueugnon, Guillaume Barbieri, François Bonnetblanc. Inter-Hemispheric Remapping between Arm Proprioception and Vision of the Hand is Disrupted by Single Pulse TMS on the Left Parietal Cortex. Brain and Cognition, 2013, 82 (2), pp.146-151. ⟨10.1016/j.bandc.2013.03.002⟩. ⟨lirmm-00805192⟩