A review on combined effects of moniliformin and co-occurring Fusarium toxins in farm animals

J-M Fremy (1) , Imourana Alassane-Kpembi (2, 3) , Isabelle P. Oswald (4) , B. Cottrill (1) , H.P. van Egmond (1)

1 Independent
2 ToxAlim - ToxAlim
3 Hôpital d'Instruction des Armées Camp Guézo
4 ToxAlim-BioToMyc - Biosynthèse & Toxicité des Mycotoxines

Co-occurrence of mycotoxins in food and feed represents the rule rather than the exception. Information about combinatory toxic effects of co-occurring mycotoxins is scarce, in particular the effects that mixtures of mycotoxins in feed may have on farm animals. This review focusses on studies on the combined effects of moniliformin and co-occurring mycotoxins in feed on farm animals. Moniliformin is a mycotoxin of emerging scientific interest, which may co-occur with many other mycotoxins, especially Fusarium mycotoxins. Oral exposure to moniliformin reduces feed consumption and body weight gain in poultry, in pigs and catfish, and induces cardiotoxic effects and/or alterations in serum biochemical and haematological parameters. In this review only experiments comparing effects as a result of the exposure to a combination of mycotoxins with effects due to the exposure to single mycotoxins were considered. Identified published studies on combined toxicity have been limited to combinations of moniliformin with either fumonisin B-1 or deoxynivalenol, and were performed with poultry, pigs, and catfish. Most of the moniliformin/fumonisin B-1 investigations involved poultry and focussed on adverse effects on feed intake, weight gain and immune response, as well as organ lesions. These studies mainly reported an interactive toxicity of moniliformin and fumonisin B-1 but did not allow identification of the type of interaction. Likewise, no indication could be given for the interaction detected for both mycotoxins on weight gains of catfish. For the moniliformin/deoxynivalenol combination, only one study with broiler chickens was found relevant. This study concluded additive or less than additive toxicity, using kidney lesions and renal tubular epithelial degeneration as endpoints. While possible interactions between moniliformin and fumonisin B-1 or deoxynivalenol were identified, the conclusions are based on limited studies and experimental designs. Further studies on the combined toxicity of moniliformin with other mycotoxins and other animal species would be needed.

Mots clés: deoxynivalenol; fumonisin B-1; adverse effects; feed; risk assessment

Domaines: Ingénierie des aliments; Toxicologie

J-M Fremy, Imourana Alassane-Kpembi, Isabelle P. Oswald, B. Cottrill, H.P. van Egmond. A review on combined effects of moniliformin and co-occurring Fusarium toxins in farm animals. World Mycotoxin Journal, 2019, 12 (3), pp.281-291. ⟨10.3920/WMJ2018.2405⟩. ⟨hal-02627929⟩