Multiplatform metabolomics for an integrative exploration of metabolic syndrome in older men

Blandine Comte (1, 2) , Stéphanie Monnerie (2) , Marion Brandolini-Bunlon (2) , Cécile Canlet (3) , Florence Castelli (4, 5, 6, 7, 8, 9, 10) , Emeline Chu-Van (4) , Benoit Colsch (4) , François Fenaille (4, 6, 7, 8) , Charlotte Joly (2) , Fabien Jourdan (11) , Natacha Lenuzza (4) , Bernard Lyan (2) , Jean-François Martin (3) , Carole Migné (2) , José Morais (12) , Mélanie Pétéra (2) , Nathalie Poupin (11) , Florence Vinson (11) , Etienne Thevenot (4) , Christophe Junot (4) , Pierrette Gaudreau (13, 14) , Estelle Pujos-Guillot (1, 2)

1 MetaboHUB-Clermont
2 UNH - Unité de Nutrition Humaine
3 ToxAlim - ToxAlim
4 MTS - Médicaments et Technologies pour la Santé
5 SMART-OMICS - Small molecule analysis and omics
6 SPI - Service de Pharmacologie et Immunoanalyse
7 LI-MS - Laboratoire Innovations en Spectrométrie de Masse pour la santé
8 MetaboHUB-IDF
9 CEA - CEA- Saclay
10 Université Paris-Saclay
11 ToxAlim-MeX - Métabolisme et Xénobiotiques
12 McGill University = Université McGill [Montréal, Canada]
13 CR CHUM - Centre de Recherche du Centre Hospitalier de l’Université de Montréal
14 UdeM - Université de Montréal

Metabolic syndrome (MetS), a cluster of factors associated with risks of developing cardiovascular diseases, is a public health concern because of its growing prevalence. Considering the combination of concomitant components, their development and severity, MetS phenotypes are largely heterogeneous, inducing disparity in diagnosis.

Mots clés: Deep phenotyping; Lipidomics; Metabolic signature; Metabolic syndrome; Metabolomics

Domaines: Sciences du Vivant [q-bio]; Alimentation et Nutrition; Bio-Informatique, Biologie Systémique [q-bio.QM]; Médecine humaine et pathologie

Blandine Comte, Stéphanie Monnerie, Marion Brandolini-Bunlon, Cécile Canlet, Florence Castelli, et al.. Multiplatform metabolomics for an integrative exploration of metabolic syndrome in older men. EBioMedicine, 2021, 69, ⟨10.1016/j.ebiom.2021.103440⟩. ⟨hal-03283772⟩