Effects of Fusarium metabolites beauvericin and enniatins alone or in mixture with deoxynivalenol on weaning piglets

Barbara Novak (1) , Amanda Lopes Hasuda (2, 3) , Mahdi Ghanbari (1) , Viviane Mayumi Maruo (3, 4) , Ana Paula F.R.L. Bracarense (2) , Manon Neves (3) , Caroline Emsenhuber (1) , Silvia Wein (1) , Isabelle P. Oswald (5) , Philippe Pinton (5) , Dian Schatzmayr (1)

1 Biomin Research Center
2 State University of Londrina = Universidade Estadual de Londrina
3 ToxAlim - ToxAlim
4 UFT - Universidade Federal do Tocantins
5 ToxAlim-BioToMyc - Biosynthèse & Toxicité des Mycotoxines

The impact of the Fusarium-derived metabolites beauvericin, enniatin B and B1 (EB) alone or in combination with deoxynivalenol (DON) was investigated in 28-29 days old weaning piglets over a time period of 14 days. The coapplication of EB and DON (EB + DON) led to a significant decrease in the weight gain of the animals. Liver enzyme activities in plasma were significantly decreased at day 14 in piglets receiving the EB + DON-containing diet compared to piglets receiving the control diet. All mycotoxin-contaminated diets led to moderate to severe histological lesions in the jejunum, the liver and lymph nodes. Shotgun metagenomics revealed a significant effect of EB-application on the gut microbiota. Our results provide novel insights into the harmful impact of emerging mycotoxins alone or with DON on the performance, gut health and immunological parameters in pigs.

Mots clés: Biomarker of effect; Cyclic hexadepsipeptides; Fungal metabolites; Gut microbiota; Histological alterations; Mycotoxins

Domaines: Sciences du Vivant [q-bio]

Barbara Novak, Amanda Lopes Hasuda, Mahdi Ghanbari, Viviane Mayumi Maruo, Ana Paula F.R.L. Bracarense, et al.. Effects of Fusarium metabolites beauvericin and enniatins alone or in mixture with deoxynivalenol on weaning piglets. Food and Chemical Toxicology, 2021, 158, pp.112719. ⟨10.1016/j.fct.2021.112719⟩. ⟨hal-03498212⟩