Differential expression of two forms of annexin 3 in human neutrophils and monocytes and along their differentiation.

V. Le Cabec (1) , F. Russo-Marie , I. Maridonneau-Parini (1)

1 LPTF - Laboratoire de Pharmacologie et de Toxicologie Fondamentales

A variant of annexin 3 (AX3) of apparent mass 36 kD has been detected in human monocytes using a specific immune serum directed against the original 33-kD form of AX3 purified from human placenta. This protein is not a phosphorylated or a glycosylated form of the 33-kD AX3 and its expression increased along monocytic differentiation whereas only the 33-kD AX3 accumulated in neutrophils. This suggests that these two forms of AX3 may play specific roles in these phagocytic cells.

Domaines: Biologie cellulaire

V. Le Cabec, F. Russo-Marie, I. Maridonneau-Parini. Differential expression of two forms of annexin 3 in human neutrophils and monocytes and along their differentiation.. Biochemical and Biophysical Research Communications, 1992, 189 (3), pp.1471-6. ⟨hal-00178928⟩