CDK Inhibitors : Cell Cycle regulators and Beyond

Arnaud Besson (1) , Steven F. Dowdy (2, 3) , James M Roberts (4)

1 LBCMCP - Laboratoire de Biologie Cellulaire et Moléculaire du Contrôle de la Prolifération
2 HHMI - Howard Hughes Medical Institute
3 UC San Diego - University of California [San Diego]
4 FHCRC - Fred Hutchinson Cancer Research Center [Seattle]

First identified as cell cycle inhibitors mediating the growth inhibitory cues of upstream signaling pathways, the cyclin-CDK inhibitors of the Cip/Kip family p21Cip1, p27Kip1, and p57Kip2 have emerged as multifaceted proteins with functions beyond cell cycle regulation. In addition to regulating the cell cycle, Cip/Kip proteins play important roles in apoptosis, transcriptional regulation, cell fate determination, cell migration and cytoskeletal dynamics. A complex phosphorylation network modulates Cip/Kip protein functions by altering their subcellular localization, protein-protein interactions, and stability. These functions are essential for the maintenance of normal cell and tissue homeostasis, in processes ranging from embryonic development to tumor suppression.

Domaines: Biologie cellulaire

Arnaud Besson, Steven F. Dowdy, James M Roberts. CDK Inhibitors : Cell Cycle regulators and Beyond. Developmental Cell, 2008, 14 (2), pp.159-169. ⟨10.1016/j.devcel.2008.01.013⟩. ⟨hal-00319908⟩