Effect of viologen-phosphorus dendrimers on acetylcholinesterase and butyrylcholinesterase activities

K. Ciepluch (1) , M. Weber (1) , Nadia Katir , A.-M. Caminade (2) , A. El Kadib (3) , B. Klajnert (1) , Jean Pierre Majoral , M. Bryszewska (1)

1 Łódź University of Technology
2 LCC - Laboratoire de chimie de coordination
3 Institute for Nanomaterials and Nanotechnology - INANOTECH (MOROCCO)

The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is the first step in checking whether new compounds can be considered as drugs for treating neurodegenerative diseases. The effect of viologen-phosphorus dendrimers on AChE and BChE activities was studied. The results show that the effects on the cholinesterase activities depend on dendrimer type and size. Viologen dendrimers can interact with the enzymes in two ways: they can bind either to a peripheral site of the enzyme or to amino acids located near the active site, inhibiting catalysis by both cholinesterases. All tested non-toxic viologen-phosphorus dendrimers inhibited the activities of both cholinesterases, showing their potential as new drugs for treating neurodegenerative diseases.

Mots clés: Acetylcholinesterase (AChE); Butyrylcholinesterase (BChE); Viologen-phosphorus dendrimers; Enzyme activity; Neurodegenerative diseases

K. Ciepluch, M. Weber, Nadia Katir, A.-M. Caminade, A. El Kadib, et al.. Effect of viologen-phosphorus dendrimers on acetylcholinesterase and butyrylcholinesterase activities. International Journal of Biological Macromolecules, 2013, 54, pp.119-124. ⟨10.1016/j.ijbiomac.2012.12.002⟩. ⟨hal-00993780⟩