PRODUCTION OF 3-10 µm MICROBUBBLES SUITED FOR ULTRASONIC IMAGING BY 2.5D NANOFLUIDIC DEVICES

Sébastien Méance (1) , Lucas Pages (1) , Anne Marie Gué (1) , Pierre Joseph (1)

1 LAAS - Laboratoire d'analyse et d'architecture des systèmes

In this paper, we propose a novel route to generate monodisperse microbubbles (MB) in the range size of 3-10 µm. Using deep reactive ion etching, we designed several "terraces" emulsification devices with depths of 200-1000 nm. We performed characterizations and systematical investigations on critical parameters such as gas pressure, liquid flow rate, and chip geometry. We experimentally show here that MB size is mainly dependent on nanochannel height. The robust monodisperse MB production and the biocompatibility of the materials opens an opportunity to integrate such systems in the future diagnostics routines.

Mots clés: Ultrasound contrast agents; Nanochannels; Nanofluidics

Domaines: Micro et nanotechnologies/Microélectronique

Sébastien Méance, Lucas Pages, Anne Marie Gué, Pierre Joseph. PRODUCTION OF 3-10 µm MICROBUBBLES SUITED FOR ULTRASONIC IMAGING BY 2.5D NANOFLUIDIC DEVICES. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014), Oct 2014, San Antonio, United States. ⟨hal-01087342⟩