Sequential Intensified Conditioning Regimen Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Intermediate or High-Risk Acute Myeloid Leukemia in Complete Remission: a Study From the ALWP of the EBMT

Florent Malard (1, 2) , Myriam Labopin (1, 2) , Gernot Stuhler (3) , Jörg Bittenbring (4) , Arnold Ganser (5) , Johanna Tischer (6) , Mauricette Michallet (7) , Nicolaus Kröger (8) , Christoph Schmid (9) , Anne Huynh (10) , Michael Hallek (11) , Bipin N Savani (12) , Mohamad Mohty (13, 1, 2) , Arnon Nagler (13, 1)

1 CHU Saint-Antoine [AP-HP]
2 CRSA - Centre de Recherche Saint-Antoine
3 German diagnostic clinic [Wiesbaden]
4 Saarland University [Saarbrücken]
5 MHH - Medizinische Hochschule Hannover = Hannover Medical School
6 University Hospital of the Ludwig-Maximilians University
7 CHU Lyon
8 University Hospital Eppendorf
9 Augsburg Hospital
10 IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole
11 University of Cologne
12 Vanderbilt University [Nashville]
13 CEREST-TC [CHU Saint-Antoine]

Post-transplant relapse is the leading cause of treatment failure in acute myeloid leukemia (AML) patients after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation (allo-HSCT). In order to improve their outcome, we evaluated the outcome of a sequential intermediate intensity conditioning regimen combining fludarabine, cytosine arabinoside, amsacrine, cyclophosphamide and either total body irradiation or busulfan (FLAMSA) in patients with intermediate or high risk AML in first or second complete remission (CR). A total of 265 patients (median age 55 years; range, 19-76 years) with AML who underwent allo-HSCT using a FLAMSA regimen were included. At the time of transplant, 216 (81.5%) were in CR1 and 49 (18.5%) in CR2.

Mots clés: Acute myeloid leukemia; complete remission; allogeneic hematopoietic-stem-cell transplantation; sequential conditioning regimen; intermediate intensity conditioning regimen

Domaines: Hématologie; Cancer

Florent Malard, Myriam Labopin, Gernot Stuhler, Jörg Bittenbring, Arnold Ganser, et al.. Sequential Intensified Conditioning Regimen Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Intermediate or High-Risk Acute Myeloid Leukemia in Complete Remission: a Study From the ALWP of the EBMT. Biology of Blood and Marrow Transplantation, 2016, ⟨10.1016/j.bbmt.2016.11.002⟩. ⟨hal-01393932⟩