Modeling Cystic Fibrosis and Mucociliary Clearance

Dominique Anne-Archard 1 Robin Chatelin 2 Marlène Murris-Espin 3 David Sanchez 4 Marc Thiriet 5 Alain Didier 3 Philippe Poncet 6
1 IMFT - Institut de mécanique des fluides de Toulouse
2 LTDS - Laboratoire de Tribologie et Dynamique des Systèmes
3 Service de pneumologie et allergologie pédiatrique [CHU Toulouse]
4 IMT - Institut de Mathématiques de Toulouse UMR5219
5 REO - Numerical simulation of biological flows
LJLL - Laboratoire Jacques-Louis Lions, UPMC - Université Pierre et Marie Curie - Paris 6, Inria de Paris
6 LMAP - Laboratoire de Mathématiques et de leurs Applications [Pau]
Abstract : This chapter considers the investigation of airway clearance efficiency and dysfunction using rheological measurements, modeling and simulations of mucus flows. The work is mainly dedicated to the respiratory epithelium dysfunction subsequently to the consumption of cilia-inhibiting drugs (e.g. nicotine) or viral and/or bacterial infections, and cystic fibrosis, although many respiratory diseases are associated with an altered mucus transport.
Keywords : Rheology Computational biology Cystic fibrosis Mucociliary clearance
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Book sections
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https://hal.inria.fr/hal-01476216
Contributor : Marc Thiriet <>
Submitted on : Friday, February 24, 2017 - 4:21:33 PM
Last modification on : Tuesday, November 19, 2019 - 2:01:17 AM
Long-term archiving on: Thursday, May 25, 2017 - 1:52:33 PM

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Dominique Anne-Archard, Robin Chatelin, Marlène Murris-Espin, David Sanchez, Marc Thiriet, et al.. Modeling Cystic Fibrosis and Mucociliary Clearance. Sid M. Becker. Modeling of microscale transport in biological processes, Academic Press, pp.113-154, 2017, 978-0-12-804595-4. ⟨10.1016/B978-0-12-804595-4.00005-5⟩. ⟨hal-01476216⟩

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