Development of pH-based ElecFET biosensors for lactate ion detection

Abstract : In this work, we report on ElecFET (Electrochemical Field Effect Transistor) devices potentially of interest for the detection of different molecules in solution. ElecFET are electrochemical microsensors in liquid phase, based on two elements: (i) a pH-sensitive chemical field effect transistor (pH-ChemFET) and (ii) a metallic microelectrode deposited around the sensitive gate. The coexistence of these two elements combines (i) potentiometric and (ii) amperometric detection effects at the microscale. Design, fabrication and experimental validation of ElecFETs based on silicon and polymer micro-technologies, are reported. We first demonstrate the detection of hydrogen peroxide (H2O2) in solution, showing a sensitivity of 5 mV/mM in the [10-100mM] concentration range. The ElecFET concept is then extended to the detection of glucose and lactate in the [1 – 30 mM] and [1 – 6 mM] concentration range respectively. The sensitivities are between 2-6 mV/mM and 8-20 mV/mM respectively.
Complete list of metadatas

Cited literature [32 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-01508091
Contributor : Pierre Temple-Boyer <>
Submitted on : Thursday, April 13, 2017 - 5:29:24 PM
Last modification on : Saturday, October 26, 2019 - 1:31:20 AM

File

manuscript_lactate-EnFET_vf.pd...
Files produced by the author(s)

Identifiers

Citation

Abdou Karim Diallo, Lyas Djeghlaf, Laurent Mazenq, Jérôme Launay, William Sant, et al.. Development of pH-based ElecFET biosensors for lactate ion detection. Biosensors and Bioelectronics, Elsevier, 2013, 40 (1), pp.291-296. ⟨10.1016/j.bios.2012.07.063⟩. ⟨hal-01508091⟩

Share

Metrics

Record views

227

Files downloads

337