Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's Disease?

Clémence Cheignon (1, 2) , Fabrice Collin (1, 2) , Peter Faller (2) , Christelle Hureau (2)

1 PHARMA-DEV - Pharmacochimie et Biologie pour le Développement
2 LCC - Laboratoire de chimie de coordination

Evaluation of the pro versus antioxidant activity of ascorbate regarding Cu(Aβ) induced reactive oxygen species production in the context of Alzheimer's disease shows that a protective activity can only be observed at high ascorbate concentration for exogenous molecules but not for the amyloid-β peptide itself.

Mots clés: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Ascorbic Acid; Coordination Complexes; Copper; Coumarins; Oxidative Stress; Reactive Oxygen Species

Domaines: Chimie de coordination; Neurobiologie

Clémence Cheignon, Fabrice Collin, Peter Faller, Christelle Hureau. Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's Disease? . Dalton Transactions, 2016, 45 (32), pp.12627-12631. ⟨10.1039/C6DT01979J⟩. ⟨hal-01591676⟩