Population pharmacokinetics of tracers: A new tool for medical imaging?

Peggy Gandia (1, 2, 3, 4, 5) , Cyril Jaudet (6) , Etienne Chatelut (1, 2, 3, 4, 7) , Didier Concordet (8)

1 CRCT - Centre de Recherches en Cancérologie de Toulouse
2 INSERM - Institut National de la Santé et de la Recherche Médicale
3 UT3 - Université Toulouse III - Paul Sabatier
4 UT - Université de Toulouse
5 Institut Fédératif de Biologie, Laboratoire de Pharmacocinétique et Toxicologie
6 Department of Radiotherapy
7 Institut Claudius Regaud
8 ToxAlim - ToxAlim

Positron emission tomography-computed tomography is a medical imaging method measuring the activity of a radiotracer chosen to accumulate in cancer cells. A recent trend of medical imaging analysis is to account for the radiotracer's pharmacokinetic properties at a voxel (three-dimensional-pixel) level to separate the different tissues. These analyses are closely linked to population pharmacokinetic-pharmacodynamic modelling. Kineticists possess the cultural background to improve medical imaging analysis. This article stresses the common points with population pharmacokinetics and highlights the methodological locks that need to be lifted.

Mots clés: drug kinetics; tomography

Mots clés: pharmacocinétique; tomographie

Domaines: Sciences du Vivant [q-bio]

Peggy Gandia, Cyril Jaudet, Etienne Chatelut, Didier Concordet. Population pharmacokinetics of tracers: A new tool for medical imaging?. Clinical Pharmacokinetics, 2017, 56 (2), pp.101-106. ⟨10.1007/s40262-016-0437-9⟩. ⟨hal-01607048⟩