PNIPAM grafted surfaces through ATRP and RAFT polymerization: Chemistry and bioadhesion

Guillaume Conzatti (1) , Sandrine Cavalier (1) , Christèle Combes (1) , J. Torrisani (2) , Nicolas Carrère (2, 3) , Audrey Tourrette (1)

1 CIRIMAT - Centre interuniversitaire de recherche et d'ingenierie des matériaux
2 CRCT - Centre de Recherches en Cancérologie de Toulouse
3 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse

Biomaterials surface design is critical for the control of materials and biological system interactions.Being regulated by a layer of molecular dimensions, bioadhesion could be effectively tailored by polymersurface grafting. Basically, this surface modification can be controlled by radical polymerization, whichis a useful tool for this purpose. The aim of this review is to provide a comprehensive overview of therole of surface characteristics on bioadhesion properties. We place a particular focus on biomaterialsfunctionalized with a brush surface, on presentation of grafting techniques for “grafting to” and “graft-ing from” strategies and on brush characterization methods. Since atom transfer radical polymerization(ATRP) and reversible addition-fragmentation chain transfer (RAFT) polymerization are the most fre-quently used grafting techniques, their main characteristics will be explained. Through the example ofpoly(N-isopropylacrylamide) (PNIPAM) which is a widely used polymer allowing tuneable cell adhesion,smart surfaces involving PNIPAM will be presented with their main modern applications.

Mots clés: Surface functionalization; Reversible addition fragmentation chain; Transfer polymerization; Atom transfer radical polymerization; Poly(N-isopropylacrylamide); Bioadhesion

Domaines: Polymères; Biomatériaux

Guillaume Conzatti, Sandrine Cavalier, Christèle Combes, J. Torrisani, Nicolas Carrère, et al.. PNIPAM grafted surfaces through ATRP and RAFT polymerization: Chemistry and bioadhesion. Colloids and Surfaces B: Biointerfaces, 2017, 151, pp.143-155. ⟨10.1016/j.colsurfb.2016.12.007⟩. ⟨hal-01625967⟩