Foam-Based Bionanocomposite Scaffold for Bone Tissue Engineering

Fany Quemeneur (1) , Corine Tourne-Peteilh (1) , Christophe Drouet (2) , Agnès Dupret-Bories (3) , Audrey Tourrette (1) , Sylvie Bégu (1) , Sophie Girod Fullana (2)

1 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
2 CIRIMAT - Centre interuniversitaire de recherche et d'ingenierie des matériaux
3 BB - Biomatériaux et Bioingénierie

The repair of large bone defects is a major clinical problem for which tissue engineering (association of a biomaterial and cells) constitutes a valuable alternative. In this domain, the architecture and the mechanical properties of the 3D scaffold aimed to support cells is of key importance to succeed in bone reconstruction. In this study, we aim to design and evaluate a bionanocomposite foam-based scaffold, exhibiting all the desired biofunctional attributes of biocompatibility, bioactivity, osteoconduction/induction, combined with potential release properties. To perform this, 2 components have been associated: (i) a biopolymer, pectin, incorporating (ii) calcium phosphate nanoparticules to provide bone apatite nucleation sites, mechanical reinforcement, and to play the role of potential drug reservoir. The goal of this study was to determine the feasibility of obtention of such bionanocomposite by foam-templating, and to study the influence of mineral particules ratio on pectin foam and final scaffold 3D architecture and properties.

Mots clés: 3D Scaffold; Bionanocomposite; Foam; Maxillofacial Reconstruction; Nanocrystalline Apatite; Pectin

Domaines: Biomatériaux; Matériaux; Matériaux

Fany Quemeneur, Corine Tourne-Peteilh, Christophe Drouet, Agnès Dupret-Bories, Audrey Tourrette, et al.. Foam-Based Bionanocomposite Scaffold for Bone Tissue Engineering. Key Engineering Materials, 2017, Bioceramics 29, 758, pp.145-149. ⟨10.4028/www.scientific.net/KEM.758.145⟩. ⟨hal-01743571⟩