Circulating tumour cells as a potential screening tool for lung cancer (the AIR study): protocol of a prospective multicentre cohort study in France

Sylvie Leroy (1, 2) , Jonathan Benzaquen (1, 3) , Andrea Mazzetta (1) , Sylvain Marchand-Adam (4, 5) , Bernard Padovani (1) , Dominique Israël-Biet (6) , Christophe M. Pison (7) , Pascal Chanez (8) , Jacques Cadranel (9) , Julien Mazières (10) , Vincent Jounieaux (11) , Charlotte Cohen (1) , Véronique Hofman (12) , Marius Ilie (12) , Paul Hofman (3) , Charles Hugo Marquette (3, 1)

1 CHU Nice - Centre Hospitalier Universitaire de Nice
2 IPMC - Institut de pharmacologie moléculaire et cellulaire
3 IRCAN - Institut de Recherche sur le Cancer et le Vieillissement
4 PRPA - Pathologies Respiratoires : Protéolyse et Aérosolthérapie
5 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
6 HEGP - Hôpital Européen Georges Pompidou [APHP]
7 Clinique de pneumologie
8 URPE - Unité des Rickettsies et pathogènes émergents
9 CHU Tenon [AP-HP]
10 IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole
11 CHU Amiens-Picardie
12 Infection bactérienne, inflammation, et carcinogenèse digestive

Lung cancer (LC) is the leading cause of death from cancer. Early diagnosis of LC is of paramount importance in terms of prognosis. The health authorities of most countries do not accept screening programmes based on low-dose chest CT (LDCT), especially in Europe, because they are flawed by a high rate of false-positive results, leading to a large number of invasive diagnostic procedures. These authorities advocated further research, including companion biological tests that could enhance the effectiveness of LC screening. The present project aims to validate early diagnosis of LC by detection and characterisation of circulating tumour cells (CTCs) in a peripheral blood sample taken from a prospective cohort of persons at high-risk of LC.

Mots clés: copd; cytopathology; lung cancer; screening

Domaines: Cancer; Médecine humaine et pathologie

Sylvie Leroy, Jonathan Benzaquen, Andrea Mazzetta, Sylvain Marchand-Adam, Bernard Padovani, et al.. Circulating tumour cells as a potential screening tool for lung cancer (the AIR study): protocol of a prospective multicentre cohort study in France. BMJ Open, 2017, 7 (12), pp.e018884. ⟨10.1136/bmjopen-2017-018884⟩. ⟨hal-01744875⟩