α,β-D-CNA induced rigidity within oligonucleotides

Christelle Dupouy (1) , Nathalie Tarrat (1) , Marie-Pierre Durrieu , Alain Vigroux (1) , Jean-Marc Escudier (1)

1 SPCMIB - Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique

Introduction of α,β-D-CNA featuring canonical values of the torsional angles α and β within oligonucleotides leads to an overall stabilization and improved rigidity of the duplex DNA as demonstrated by UV experiments, circular dichroism and corroborated by molecular dynamics simulations.

Domaines: Chimie-Physique [physics.chem-ph]

Christelle Dupouy, Nathalie Tarrat, Marie-Pierre Durrieu, Alain Vigroux, Jean-Marc Escudier. α,β-D-CNA induced rigidity within oligonucleotides. Organic & Biomolecular Chemistry, 2008, 6 (16), ⟨10.1039/B809775E⟩. ⟨hal-01755288⟩