α,β-D-CNA featuring canonical and noncanonical α/β torsional angles behaviours within oligonucleotides
Résumé
α,β-D-CNA building blocks featuring either canonical gauche(−) or noncanonical gauche(+) values of the nucleic acids sugar phosphate backbone torsional angle α have been introduced into oligonucleotides, and provide new insight on conformational restriction impact on duplex formation ability by means of UV experiments and molecular dynamics simulations.