Deprotonation-alkylation of alkyl cyanides under sonochemical conditions

Jacques Berlan (1) , Henri Delmas (1) , Isabelle Duée (2) , J. L. Luche (3) , L. Vuiglio (4)

1 LGC - Laboratoire de Génie Chimique
2 Poudres et procédés - Ecole des Mines Albi-Carmaux
3 UT3 - Université Toulouse III - Paul Sabatier
4 SANOFI Recherche

Deprotonation-alkylation of n-alkyl cyanides can be readily effected by an alkyl halide in the presence of sodium in a one pot procedure. Yields are generally better than in the usual methods, and the overall reaction conditions have important advantages in terms of ease and simplicity compatible with preparative scale-up.

Domaines: Sciences de l'ingénieur [physics]

Jacques Berlan, Henri Delmas, Isabelle Duée, J. L. Luche, L. Vuiglio. Deprotonation-alkylation of alkyl cyanides under sonochemical conditions. Synthetic Communications, 1994, 24 (9), pp.1253 - 1260. ⟨10.1080/00397919408011725⟩. ⟨hal-01851814⟩