Ternary diagram: alpha-(3-benzoylphenyl)-propionic acid (ketoprofen) in acetone-water mixtures at different temperatures. Experimental data and predicted results

Fabienne Espitalier (1) , Béatrice Biscans (1) , P. Sere Peyrigain , C Laguérie (1)

1 LGC - Laboratoire de Génie Chimique

Experimental data are determined for a ternary system, ketoprofen-acetone-water, at various temperatures and atmospheric pressure. Specific procedures are applied. The diagram exhibits five regions: one homogeneous , three two-phase (two liquid-solid and one liquid-liquid equilibria) and one three-phase zones. The variation of the solubility of ketoprofen in acetone-water mixtures is interpreted by analysing the molecular forces induced in the solution according to the acetone mass ratio in the mixture. The validity of semi-empirical models is tested for liquid-solid and liquid-liquid equilibria by comparing the calculated values with the experimental ones. The agreement depends on the precision of the estimated parameters used for calculations.

Mots clés: Experimental data; UNIQUAC model; Polar interactions; Multicomponent; Phase equilibria

Domaines: Génie des procédés; Génie chimique; Pharmacie galénique

Fabienne Espitalier, Béatrice Biscans, P. Sere Peyrigain, C Laguérie. Ternary diagram: alpha-(3-benzoylphenyl)-propionic acid (ketoprofen) in acetone-water mixtures at different temperatures. Experimental data and predicted results. Fluid Phase Equilibria, 1995, 113 (1-2), pp.151-171. ⟨10.1016/0378-3812(95)02806-8⟩. ⟨hal-01868133⟩