Investigations on dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs

Nabil El brahmi (1, 2) , Serge M. Mignani (3, 4, 5) , Joachim Caron (1, 2) , S. El Kazzouli (2) , Mosto M. Bousmina (2) , A.-M. Caminade (1) , Thierry Cresteil (6) , Jean Pierre Majoral (1)

1 LCC - Laboratoire de chimie de coordination
2 Euromed Research Center, Engineering Division
3 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques
4 UPD5 - Université Paris Descartes - Paris 5
5 USPC - Université Sorbonne Paris Cité
6 IPSIT - Ingénierie et Plateformes au Service de l'Innovation Thérapeutique de Paris Saclay

The well-known reactive diuretic ethacrynic acid (EA, Edecrin), with low antiproliferative activities, was chemically modified and grafted onto phosphorus dendrimers and the corresponding simple branched phosphorus dendron-like derivatives affording novel nanodevices showing moderate to strong antiproliferative activities against liquid and solid tumor cell lines, respectively.

Domaines: Chimie de coordination

Nabil El brahmi, Serge M. Mignani, Joachim Caron, S. El Kazzouli, Mosto M. Bousmina, et al.. Investigations on dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs. Nanoscale, 2015, 7 (9), pp.3915-3922. ⟨10.1039/C4NR05983B⟩. ⟨hal-01923226⟩