Synthesis, structures, and biological studies of heterobimetallic Au(I)-Ru(II) complexes involving N-heterocyclic carbene-based multidentate ligands

Luca Boselli (1, 2) , Maëlle Carraz (2) , S. Mazeres (3) , Lucie Paloque (2) , German Gonzalez-Aspajo (2) , Françoise Benoit-Vical (1, 2) , Alexis Valentin (2) , Catherine Hemmert (1, 2) , Heinz Gornitzka (1, 2)

1 LCC - Laboratoire de chimie de coordination
2 PHARMA-DEV - Pharmacochimie et Biologie pour le Développement
3 IPBS - Institut de pharmacologie et de biologie structurale

Three heterobimetallic gold(I)-ruthenium(II) complexes containing heteroditopic bipyridine-N-heterocyclic carbene (NHC) ligands were synthesized and fully characterized by spectroscopic methods and in one case by single-crystal X-ray diffraction. In addition, the in vitro cytotoxic, antileishmanial, and antimalarial activities of these new heterobimetallic complexes were assessed. Moreover, the photophysical properties of two compounds have been used to localize them in tumor cells by confocal microscopy.

Mots clés: STEPWISE METALATION STRATEGY; IN-VITRO EVALUATION; THIOREDOXIN REDUCTASE; GOLD(III) COMPLEXES; RUTHENIUM(II) COMPLEXES; CYTOTOXIC METALLODRUGS; TRICARBENE LIGAND; ANTICANCER AGENTS; DINUCLEAR GOLD(I); QUADRUPLEX DNA

Domaines: Chimie de coordination

Luca Boselli, Maëlle Carraz, S. Mazeres, Lucie Paloque, German Gonzalez-Aspajo, et al.. Synthesis, structures, and biological studies of heterobimetallic Au(I)-Ru(II) complexes involving N-heterocyclic carbene-based multidentate ligands. Organometallics, 2015, 34 (6), pp.1046-1055. ⟨10.1021/om501158m⟩. ⟨hal-01925137⟩