Rh(III)-catalyzed synthesis of multisubstituted isoquinolines from benzylamines and diazo compounds

Xing Lin (1) , Rémi Chauvin (2, 3, 1) , Yunliang Yu (1) , Lianhui Wang (1) , Linhua Xu (1) , Xiuling Cui (1)

1 HQU - Huaqiao University
2 LCC - Laboratoire de chimie de coordination
3 UT3 - Université Toulouse III - Paul Sabatier

Multisubstituted isoquinolines have been prepared by Rh(III)-catalyzed cyclization of benzylamines with diazo compounds via aryl C-H bond activation using molecular oxygen from air as an oxidant. This method features mild reaction conditions, simple catalytic system, tolerance of a broad range of substrates, high efficiency and regioselectivity.

Domaines: Chimie de coordination

Xing Lin, Rémi Chauvin, Yunliang Yu, Lianhui Wang, Linhua Xu, et al.. Rh(III)-catalyzed synthesis of multisubstituted isoquinolines from benzylamines and diazo compounds. ChemistrySelect, 2017, 2 (8), pp.2383-2387. ⟨10.1002/slct.201700270⟩. ⟨hal-01939398⟩