A promising dual mode SPECT/CT imaging platform based on 99mTc-labeled multifunctional dendrimer-entrapped gold nanoparticles

Shihui Wen (1) , Lingzhou Zhao (2) , Qinghua Zhao (3) , Du Li (4) , Changcun Liu (2) , Zhibo Yu (4) , Mingwu Shen (1) , Jean Pierre Majoral (5) , Serge Mignani (6, 7, 8) , Jinhua Zhao (2) , Xiangyang Shi (4, 1)

1 CCEB - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University
2 Shanghai Jiao Tong University School of Medicine
3 Department of Orthopaedics, Shanghai General Hospital
4 State Key Laboratory for Fiber & Material Modification of Donghua University
5 LCC - Laboratoire de chimie de coordination
6 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques
7 UPD5 - Université Paris Descartes - Paris 5
8 USPC - Université Sorbonne Paris Cité

Multifunctional 99mTc-labeled dendrimer-entrapped gold nanoparticles (99mTc-Au DENPs) were designed and synthesized. Our results show that the type of surface groups (acetyl or hydroxyl) significantly impact the biodistribution profile of the 99mTc-Au DENPs, thereby allowing for preferential SPECT/CT imaging of different organs.

Domaines: Chimie de coordination

Shihui Wen, Lingzhou Zhao, Qinghua Zhao, Du Li, Changcun Liu, et al.. A promising dual mode SPECT/CT imaging platform based on 99mTc-labeled multifunctional dendrimer-entrapped gold nanoparticles. Journal of materials chemistry‎ B, 2017, 5 (21), pp.3810-3815. ⟨10.1039/C7TB00543A⟩. ⟨hal-01945629⟩