DNA twist and bending govern the denaturation bubble slow dynamics

Manoel Manghi (1, 2) , Anil K. Dasanna (1, 2) , Nicolas Destainville (1, 2) , John Palmeri (3)

1 PhyStat - Physique Statistique des Systèmes Complexes (LPT)
2 LPT - Laboratoire de Physique Théorique
3 L2C - Laboratoire Charles Coulomb

The closure of long equilibrated denaturation bubbles in DNA is studied using Brownian dynamics simulations. A minimal mesoscopic model is used where the double helix is made of two interacting bead-spring freely rotating strands, with a nonzero torsional modulus in the duplex state.

Domaines: Biophysique [physics.bio-ph]; Matière Molle [cond-mat.soft]; Mécanique statistique [cond-mat.stat-mech]

Manoel Manghi, Anil K. Dasanna, Nicolas Destainville, John Palmeri. DNA twist and bending govern the denaturation bubble slow dynamics. Soft Matter 2013, Sep 2013, Rome, Italy. ⟨hal-01948354⟩