Low Volume and Label-Free Molecules Characterization and Cell Monitoring with Microwave Dielectric Spectroscopy

Katia Grenier (1) , Amar Tamra (1) , Amel Zedek (1) , Guillaume Poiroux (1) , François Artis (1) , Tong Chen (1) , Wenli Chen (1) , M Poupot (2) , J-J Fournié (2) , David Dubuc (1)

1 LAAS-MH2F - Équipe Micro et nanosystèmes HyperFréquences Fluidiques
2 CRCT - Centre de Recherches en Cancérologie de Toulouse

Microwave dielectric spectroscopy is an attractive technique for non-destructive characterization of materials. This paper focus on its development for molecular and cellular analysis using microscale sensors. It especially focuses on the possible selectivity of the technique through the characterization of bio-molecules in aqueous solution, as well as on the possible monitoring of cells reactions at the single cell level. This last capability opens the door to kinetic evaluation, which is particularly interesting and important to evaluate any stimulus on cells, such as drugs, electrical signals and even the presence of other cell.

Mots clés: molecules; dielectric spectroscopy; microwave; cells

Domaines: Electromagnétisme; Micro et nanotechnologies/Microélectronique; Imagerie; Biochimie [q-bio.BM]

Katia Grenier, Amar Tamra, Amel Zedek, Guillaume Poiroux, François Artis, et al.. Low Volume and Label-Free Molecules Characterization and Cell Monitoring with Microwave Dielectric Spectroscopy. IEEE International Microwave Bio Conference (IMBioC 2018), Jun 2018, Philadelphie, PA, United States. 3p., ⟨10.1109/IMBIOC.2018.8428873⟩. ⟨hal-01951457⟩