Sub-microliter microwave dielectric spectroscopy for identification and quantification of carbohydrates in aqueous solution

François Artis (1) , David Dubuc (1) , J-J Fournié (2) , M Poupot (2) , Katia Grenier (1)

1 LAAS-MH2F - Équipe Micro et nanosystèmes HyperFréquences Fluidiques
2 CRCT - Centre de Recherches en Cancérologie de Toulouse

This paper presents the technique and associated miniature RF biosensor dedicated to the microwave dielectric spectroscopy of carbohydrates in aqueous solution. Small amounts of liquid in the range of microliter are required. This sensor includes an area for electromagnetic field analysis that operates in the near field, while a microfluidic channel allows precisely bringing and locating the liquid solution to be studied on the sensing zone. Different carbohydrates were measured from 40 MHz to 40 GHz with relevant concentrations for biologists and chemists. Derived from the extracted complex relative permittivity of the examined liquids, this paper shows that each biomolecules type exhibits a specific dielectric signature, which allows their identification and quantification.

Mots clés: Microwave; coplanar waveguide; biosensor; dielectric spectroscopy; carbohydrates

Domaines: Electromagnétisme; Micro et nanotechnologies/Microélectronique; Biotechnologies

François Artis, David Dubuc, J-J Fournié, M Poupot, Katia Grenier. Sub-microliter microwave dielectric spectroscopy for identification and quantification of carbohydrates in aqueous solution. IEEE Topical Conference on Biomedical Wireless Technologies, Networks, and Sensing Systems (BioWireleSS 2015), Jan 2015, San Diego, United States. 5p., ⟨10.1109/BIOWIRELESS.2015.7152125⟩. ⟨hal-01951678⟩