Magnetite Fe3O4 has no intrinsic peroxidase activity, and is probably not involved in Alzheimer's oxidative stress

Michelle Gumpelmayer (1, 2) , Michel Nguyen (1) , Gábor Molnár (1) , Azzedine Bousseksou (1) , B. Meunier (1, 3, 4) , Anne Robert (1)

1 LCC - Laboratoire de chimie de coordination
2 UT3 - Université Toulouse III - Paul Sabatier
3 UT - Université de Toulouse
4 School of Chemical Engineering and Light Industry, Guangdong University of Technology

Despite stated in some highly cited articles, magnetite is devoided of peroxidase activity. In fact, this very stable mixed valence FeIIO[n.8901]FeIII2O3 complex is not catalytically competent to oxidize std. peroxidase substrates, esp. at the biol. relevant pH value of 7.4. In addn., magnetite whose deleterious redox activity has been suspected in Alzheimer's disease brain damages, does not significantly interact with amyloid peptide Aβ in vitro, and is not able to induce, either in the presence or absence of Aβ, the reductive activation of dioxygen, the first step of an oxidative stress. In fact, this highly insol. mineral iron deriv. is probably not involved in the oxidative damage of brain neurons of patients with AD.

Domaines: Chimie de coordination

Michelle Gumpelmayer, Michel Nguyen, Gábor Molnár, Azzedine Bousseksou, B. Meunier, et al.. Magnetite Fe3O4 has no intrinsic peroxidase activity, and is probably not involved in Alzheimer's oxidative stress. Angewandte Chemie International Edition, 2018, 57, pp.14758 -14763. ⟨10.1002/anie.201807676⟩. ⟨hal-01954192⟩