Dendrimers in combination with natural products and analogues as anti-cancer agents

Serge Mignani (1, 2, 3) , Joao Rodrigues (4, 5) , Helena Tomas (4) , M. Zablocka (6) , Xiangyang Shi (5) , A.-M. Caminade (7) , Jean Pierre Majoral (7)

1 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques
2 UPD5 - Université Paris Descartes - Paris 5
3 USPC - Université Sorbonne Paris Cité
4 Centro de Química da Madeira
5 State Key Laboratory for Fiber & Material Modification of Donghua University
6 Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences
7 LCC - Laboratoire de chimie de coordination

For the first time, an overview of dendrimers in combination with natural products and analogues as anti-cancer agents is presented. This reflects the development of drug delivery systems, such as dendrimers, to tackle cancers. The most significant advantages of using dendrimers in nanomedicine are their high biocompatibility, good water solubility, and their entry - with or without encapsulated, complexed or conjugated drugs - through an endocytosis process. This strategy has accelerated over the years in order to develop nanosystems as nanocarriers, to decrease the intrinsic toxicity of anti-cancer agents, to decrease the drug side effects, to increase the efficacy of the treatment, and consequently to improve patient compliance.

Domaines: Chimie de coordination

Serge Mignani, Joao Rodrigues, Helena Tomas, M. Zablocka, Xiangyang Shi, et al.. Dendrimers in combination with natural products and analogues as anti-cancer agents. Chemical Society Reviews, 2018, 47, pp.514-532. ⟨10.1039/C7CS00550D⟩. ⟨hal-01957968⟩