Cyclotriphosphazene core-based dendrimers for biomedical applications: an update on recent advances

Le Wang (1) , Yun-Xia Yang (1) , Xiangyang Shi (2, 3) , Serge Mignani (4, 5, 6) , A.-M. Caminade (7) , Jean Pierre Majoral (7)

1 College of Chemistry and Chemical Engineering
2 CCEB - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University
3 Centro de Química da Madeira
4 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques
5 UPD5 - Université Paris Descartes - Paris 5
6 USPC - Université Sorbonne Paris Cité
7 LCC - Laboratoire de chimie de coordination

This review is focused on the recent use of cyclotriphosphazene-based dendrimers in biomedicine. Since its synthesis for the first time in 1834, cyclotriphosphazene has been an important compound of phosphorus chemistry as a scaffold, and a large number of cyclotriphosphazene derivatives have been synthesized and applied in various fields such as biology, catalysis, fluorescence, nanomaterials, etc. Today, one of the most important uses concerns its biomedical applications. In this review, the recent developments (since 2012) of cyclotriphosphazene for major pharmaceutical applications are highlighted and analyzed.

Domaines: Chimie de coordination

Le Wang, Yun-Xia Yang, Xiangyang Shi, Serge Mignani, A.-M. Caminade, et al.. Cyclotriphosphazene core-based dendrimers for biomedical applications: an update on recent advances. Journal of materials chemistry‎ B, 2018, 6 (6), pp.884-895. ⟨10.1039/C7TB03081A⟩. ⟨hal-01957973⟩