Acid-Catalyzed Rearrangement of Epoxides

Maryse Gouygou (1, 2) , Martine Urrutigoity (1, 2)

1 LCC - Laboratoire de chimie de coordination
2 Toulouse INP - Institut National Polytechnique (Toulouse)

This chapter summarizes recent advances in the development of acid-catalyzed rearrangements of epoxides and highlights the wide variety of acids used, such as Brønsted acids, Lewis acids derived from the main group, transition metals, and other metals including lanthanides as well as solid Brønsted and Lewis acids. Special attention is paid to selective key step reactions leading to intermediates of drugs and fine chemicals.

Mots clés: Brønsted acid Drug intermediates Epoxides Lewis acid Rearrangement Ring opening Solid acid

Domaines: Chimie de coordination

Maryse Gouygou, Martine Urrutigoity. Acid-Catalyzed Rearrangement of Epoxides. Knochel, P. and Molander, G. A. Comprehensive Organic Synthesis II (Second edition), 3.15, Elsevier, pp.757-794, 2014, 978-0-080-97743-0. ⟨hal-02042482⟩